Ozempic Mouth: The Celebrity Weight Loss Craze With a Hidden Cost

Health Desk – Martian Smiles Lab

New Delhi, UPDATED May 20, 2025 11:29 PM

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Ozempic mouth is becoming a growing concern among celebrities and everyday users alike. While the weight-loss drug Ozempic is praised for rapid results, many are now reporting unexpected oral health side effects — including facial aging, dry mouth, and gum sensitivity. In this article, our Health Desk – Martian Smiles Lab breaks down the science behind Ozempic’s impact on your smile and why oral care should not be an afterthought.

Celebrities like Oprah Winfrey, Elon Musk and Karan Johar Celebrity faces showing Ozempic weight loss side effects like sunken cheeks.

In the race for rapid transformation, celebrities like Oprah Winfrey, Elon Musk, and Amy Schumer have reportedly used Ozempic, a medication originally designed for type 2 diabetes. Indian filmmaker Karan Johar & Ram Kapoor, although they have denied using Ozempic, remain at the center of speculation and online chatter linking their transformations to the drug. While many have praised its weight-loss benefits, a new trend is catching public attention—and not for the right reasons. It’s being called “Ozempic Face.”

From Katy Perry’s sunken cheeks to Sharon Osbourne’s drastically altered look, the internet is abuzz with side-by-side images of stars who appear to have aged dramatically in a short span. But what’s really going on?

What Is Ozempic, and Why Is It Popular?

Ozempic (semaglutide) is a GLP-1 receptor agonist, used primarily to manage blood sugar levels in diabetic patients. It also slows gastric emptying and suppresses appetite—making it a go-to for off-label weight loss.

Celebrities and influencers, often under pressure to maintain a certain image, have increasingly turned to Ozempic for rapid results.

How Ozempic Affects Your Face & Mouth

When you lose weight quickly—especially in your 40s, 50s, and beyond—facial fat disappears too, leading to:

Facial hollowing and aging effects potentially linked to weight-loss medications like Ozempic.
  • Hollow cheeks
  • Sagging skin
  • More visible wrinkles
  • Droopy jaws
  • Thinner lips and temples

This aging effect is intensified by Ozempic’s rapid action. In fact, some plastic surgeons report a surge in fillers and facelifts among former Ozempic users trying to “reclaim” their youth.

Dr. Paul Jarrod Frank, a celebrity dermatologist, coined the term “Ozempic Face” after observing this pattern in patients seeking cosmetic help post-weight loss.

Ozempic Mouth: The Overlooked Side Effect

While much attention is on facial aesthetics, oral health professionals are sounding the alarm too. Ozempic and similar drugs may indirectly impact dental health by:

1. Dry Mouth (Xerostomia)

Reduced saliva production increases the risk of:

  • Tooth decay
  • Gum disease
  • Mouth ulcers
  • Bad breath
2. Nutrient Deficiency

Appetite suppression can lead to:

  • Low calcium and vitamin D intake
  • Weakened tooth enamel
  • Delayed healing after dental procedures
3. Gastrointestinal Reflux

Some users experience acid reflux, which can erode tooth enamel and irritate soft tissues in the mouth.

“If you’re using Ozempic, regular dental checkups become more important than ever,” says Dr. Bibhakar Ranjan, oral health advocate.

While the world is talking about “Ozempic Face,” there’s an equally concerning phenomenon below the nose—Ozempic Mouth.

The term was coined by international dental surgeon and oral health advocate Dr. Bibhakar Ranjan, after observing a pattern of oral issues in patients regularly using Ozempic and similar weight loss medications.

Patients on long-term Ozempic therapy began reporting symptoms such as:

  • Persistent dry mouth (xerostomia)
  • Increased incidence of cavities and gum inflammation
  • Burning mouth syndrome
  • Delayed healing after dental surgeries or cleanings

“The mouth is an early warning system for overall health,” says Dr. Ranjan. “When powerful medications alter your metabolism, the oral cavity often reacts first. Ignoring these signs can lead to irreversible damage.”

Celebrities Speaking Out

Even Elon Musk joined the conversation around rapid weight loss when he posted a photo of himself as a slimmed-down Santa, humorously captioned ‘Ozempic Santa,’ highlighting just how mainstream the drug’s image has become.

  • Amy Schumer admitted quitting Ozempic due to feeling sick and unwell.
  • Sharon Osbourne, now visibly thinner, stated she “lost too much weight” and regrets the extreme change.
  • Karan Johar has been trolled for looking older—while neither confirming nor denying Ozempic use, public speculation continues.

Despite the glitz, the underlying message is clear: quick fixes can have long-term costs—especially when it comes to health and confidence.

The global conversation around Ozempic continues to grow — not just among patients and doctors, but even political leaders.

In a recent video, Robert F. Kennedy Jr. highlighted the huge price gap of Ozempic between Europe and the United States, calling out big pharmaceutical companies and advocating for lower costs:

Meanwhile, Donald Trump indirectly referenced Ozempic while joking about his seriously overweight friend taking “fat shot drug.” — a nod many interpreted as a reference to the drug’s rising popularity:

Conclusion: Think Beyond the Mirror

Ozempic might trim your waistline, but it could also drain the youth from your face and the strength from your smile. Whether you’re a celebrity or a health-conscious individual, it’s important to consider the whole-body impact before jumping on the trend.

Explore more: Read our article on celebrity dental trends or check out the Freddie Mercury and Aimee Lou Wood article to discover how dental aesthetics shape public perception..